HaptoTech ATRS

The field of regenerative medicine constantly pushes the boundaries of innovation to meet the complex challenges of bone repair and tissue regeneration. Traditional grafting materials, while functional to a degree, often fall short in achieving sufficient regeneration. In response to these limitations, HaptoTech ATRS has revolutionized tissue engineering with its proprietary ATRS (Advanced Tissue Regeneration System) technology.

This groundbreaking process has culminated in the creation of AmGraft®, a next-generation bone grafting material that enhances the natural regenerative potential of human dentin matrix (HDM), and establishes new benchmarks in bone regeneration and clinical efficiency.

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AmGraft is Engineered with HaptoTech ATRS

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Enhanced Cell Migration (Hapto)

Our meticulously processed surface promotes superior cell migration. This is pivotal as cells must migrate efficiently to the injury site to initiate the repair process. The “hapto” nature of our surface establishes a conducive environment for this migration.

Optimal Cell Spreading (Taxis)

Cell spreading, or taxis, is fundamental for cells to interact with their environment and each other. HaptoTech ATRS promotes cell spreading, which is crucial for their subsequent functions, including proliferation.

Promoted Cell Proliferation

Once cells have migrated and spread, they must proliferate to create a critical mass for effective tissue regeneration. Our surface preparation nurtures this proliferation, ensuring a rapid and efficient cellular response.

Facilitated Cell Differentiation

For bone tissue regeneration, it is imperative that progenitor cells differentiate into osteoblasts. HaptoTech ATRS’s surface acts as a guide, aiding cells in adopting their necessary roles, ensuring successful bone tissue formation and maturation.

Central to HaptoTech ATRS innovation is the advanced engineering of the human dentin matrix (HDM). HaptoTech ATRS proprietary technology focuses on retaining and enhancing the bioactive components of HDM.

The Science Behind HaptoTech ATRS:
Surface Engineering Explained.

Decontamination

  • The base material is carefully selected and prepared to ensure uniformity and purity.
  • Initial cleaning procedures remove any contaminants or residues, setting the stage for further modifications.

Micro-structuring

  • Advanced techniques, and chemical treatments, are used to create a microstructured surface.
  • This microstructuring increases the surface area and creates a topography that promotes cellular adhesion and migration.

Optimization

  • Advanced techniques, and chemical treatments, are used to create a microstructured surface.
  • This microstructuring increases the surface area and creates a topography that promotes cellular adhesion and migration.

By decontamination, microstructuring and optimising of this natural matrix, HaptoTech ATRS ensures the preservation of essential regenerative proteins, including bone morphogenetic proteins (BMPs) and transforming growth factor-beta (TGF-β). These bioactive molecules play critical roles in activating pathways, such as the SMAD signaling cascade, which governs osteoblast differentiation, extracellular matrix production, and mineralization—the fundamental processes for bone regeneration.

In addition to the SMAD pathway, AmGraft® enhances integrin-mediated signaling by upregulating integrins like ITGA2 and ITGB1, which are pivotal in promoting cellular adhesion, migration, and the formation of a supportive osteogenic microenvironment. These combined pathways enable AmGraft® to deliver superior bone-to-implant contact (BIC), accelerated healing, and reliable integration with native bone tissue. Unlike traditional grafting materials that serve as passive scaffolds, AmGraft® actively participates in the regenerative process by releasing bioactive molecules that orchestrate the cascade
of events necessary for successful bone repair.

HaptoTech’s ATRS technology goes beyond preserving biological activity—it also eliminates immunogenic elements and optimizes the material’s structural integrity. Through advanced microstructuring, ATRS creates a graft surface with increased area and topographical features that facilitate cellular adhesion and integration. This ensures that AmGraft® provides not only exceptional biocompatibility but also unparalleled consistency and safety in clinical applications.

Rigorous preclinical and clinical evaluations have validated AmGraft®’s performance, demonstrating its ability to stimulate new bone formation, integrate seamlessly with host tissue, and deliver predictable outcomes across diverse clinical settings. These studies highlight the material’s transformative potential, showcasing its enhanced BIC and ability to address even the most demanding regenerative challenges.